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glycerol phenylbutyrate will minimize the extent or influence of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Glycerol phenylbutyrate is a weak inducer of CYP3A4. Monitor for diminished efficacy of CYP3A4 substrates that have a slim therapeutic index.In only one-evening, double-blind, parallel-team trial